NTR Mahanayakudu is the continuation of the two-part biopic N.T.R: Kathanayakudu. The film celebrates the life and times of the legendary actor and politician Nandamuri Taraka Rama Rao who ruled the world of Telugu cinema for over four decades. The movie throws light on the personal and professional life of the National Award winning actor and famous politician who also served as the Chief Minister of Andhra Pradesh for seven years. NTR's son Nandamuri Balakrishna resumes the role of his father.