Based on the Vertigo comic book miniseries of the same name, the film is a crime thriller set in the 1970s Hell's Kitchen in New York City starring Melissa McCarthy (Kathy), Tiffany Haddish (Ruby) and Elizabeth Moss (Claire) as housewives of Irish mobsters. When their husbands are arrested by the FBI, the women take up the charge of the syndicate of crime operations and eventually become the commanding mobsters of 'The Kitchen'.